Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses.
Identifieur interne : 000176 ( 1968/Analysis ); précédent : 000175; suivant : 000177Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses.
Auteurs : R. Pyhã LãSource :
- The Journal of Hygiene [ 0022-1724 ] ; 1985.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (analyse), Finlande, Flambées de maladies (immunologie), Grippe humaine (immunologie), Humains, Hémagglutinines virales (immunologie), Immunité, Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Spécificité des anticorps, Virus de la grippe A (immunologie).
- MESH :
- analyse : Anticorps antiviraux.
- immunologie : Flambées de maladies, Grippe humaine, Hémagglutinines virales, Sialidase, Virus de la grippe A.
- Finlande, Humains, Immunité, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Spécificité des anticorps.
- Wicri :
- geographic : Finlande.
English descriptors
- KwdEn :
- Antibodies, Viral (analysis), Antibody Specificity, Disease Outbreaks (immunology), Finland, Hemagglutinins, Viral (immunology), Humans, Immunity, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus (immunology), Influenza, Human (immunology), Neuraminidase (immunology).
- MESH :
- chemical , analysis : Antibodies, Viral.
- chemical , immunology : Hemagglutinins, Viral, Neuraminidase.
- geographic : Finland.
- immunology : Disease Outbreaks, Influenza A virus, Influenza, Human.
- Antibody Specificity, Humans, Immunity, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype.
Abstract
The incidence of haemagglutination inhibition (HI) antibody (titre greater than or equal to 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, the lowest being in people born during the period 1901-10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses. At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of 'original antigenic sin' and to the threat of re-emergence of the H2N2 viruses.
Url:
PubMed: 4067298
PubMed Central: 2129551
Affiliations:
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PMC:2129551Le document en format XML
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Pyhã Lã</name></author></analytic><series><title level="j">The Journal of Hygiene</title><idno type="ISSN">0022-1724</idno><imprint><date when="1985">1985</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (analysis)</term><term>Antibody Specificity</term><term>Disease Outbreaks (immunology)</term><term>Finland</term><term>Hemagglutinins, Viral (immunology)</term><term>Humans</term><term>Immunity</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (immunology)</term><term>Influenza, Human (immunology)</term><term>Neuraminidase (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (analyse)</term><term>Finlande</term><term>Flambées de maladies (immunologie)</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Hémagglutinines virales (immunologie)</term><term>Immunité</term><term>Sialidase (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Spécificité des anticorps</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Finland</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Flambées de maladies</term><term>Grippe humaine</term><term>Hémagglutinines virales</term><term>Sialidase</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Disease Outbreaks</term><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Antibody Specificity</term><term>Humans</term><term>Immunity</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Finlande</term><term>Humains</term><term>Immunité</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Spécificité des anticorps</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The incidence of haemagglutination inhibition (HI) antibody (titre greater than or equal to 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, the lowest being in people born during the period 1901-10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses. At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of 'original antigenic sin' and to the threat of re-emergence of the H2N2 viruses.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Pyha La, R" sort="Pyha La, R" uniqKey="Pyha La R" first="R." last="Pyhã Lã">R. Pyhã Lã</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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